Genetic Dissection of Complex Traits: From Functional Mapping to Systems Mapping

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Genetic Dissection of Complex Traits: From Functional Mapping to Systems Mapping

Many statistical tools have been developed to map and study the genetic architecture of complex phenotypes important to agriculture, biology, and biomedicine [1-9]. Thanks to recent advances in sequencing and genotyping technologies, DNA-based marker data crucial for genetic mapping can be generated almost with no limit. A new challenge that faces methodological development is how to dissect a ...

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FunMap: functional mapping of complex traits

SUMMARY FunMap is a Web-based user interface designed to map quantitative trait loci (QTL) affecting function-valued traits or infinite-dimensional traits in well-structured pedigrees or natural populations. User input includes three files: longitudinal trait data, marker genotypes and/or a linkage map. This software allows for a systematic genome-wide scan and significance test of QTL througho...

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A fast algorithm for functional mapping of complex traits.

By integrating the underlying developmental mechanisms for the phenotypic formation of traits into a mapping framework, functional mapping has emerged as an important statistical approach for mapping complex traits. In this note, we explore the feasibility of using the simplex algorithm as an alternative to solve the mixture-based likelihood for functional mapping of complex traits. The results...

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A Bayesian Algorithm for Functional Mapping of Dynamic Complex Traits

Functional mapping of dynamic traits measured in a longitudinal study was originally derived within the maximum likelihood (ML) context and implemented with the EM algorithm. Although ML-based functional mapping possesses many favorable statistical properties in parameter estimation, it may be computationally intractable for analyzing longitudinal data with high dimensions and high measurement ...

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Ordered subset analysis in genetic linkage mapping of complex traits.

Etiologic heterogeneity is a fundamental feature of complex disease etiology; genetic linkage analysis methods to map genes for complex traits that acknowledge the presence of genetic heterogeneity are likely to have greater power to identify subtle changes in complex biologic systems. We investigate the use of trait-related covariates to examine evidence for linkage in the presence of heteroge...

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ژورنال

عنوان ژورنال: Journal of Biometrics & Biostatistics

سال: 2012

ISSN: 2155-6180

DOI: 10.4172/2155-6180.1000e119